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In Not Cancer when their friendship had broken up, he went so far as to try to pay Wilson to talk about things unrelated to his current case. In addition, as House often criticizes him for, Wilson tends to be a "clingy" friend/date. This is because of how much he cares about other people, resulting in him wanting to be as involved with them as possible. Wilson has to intervene once again when he realizes House is plotting to get nerve tissue from a patient who is insensitive to pain in an attempt to graft the nerve cells to his own.

Fictional character on House / From Wikipedia, the free encyclopedia

Wilson did well in school and was also talented athletically, he was the captain of his high school's varsity tennis team and also played the sport in college. His unwavering loyalty towards House is regarded as odd, considering that he is portrayed as a generally kind, reasonable person in contrast to House’s moral bankruptcy. There have been numerous hints throughout the show that the intensity of his devotion is a result of some underlying romantic attraction to his friend (“If you’re going to say that you’ve always been secretly gay for me, everyone always just kinda assumed,” — House, The C-Word).
Character Analysis
But he also is able to deeply empathize with his patients and friends, and is known to be very compassionate as a doctor. And he seems to be the only one who is truly willing to put up with House despite House’s regular ill-temper. In contrast to his own personality and demeanor, Wilson generally finds friends in much darker and more dour people, such as his best friend House or girlfriend Amber. In fact, House and Wilson are so very different from each other, that the close pair of friends can be said to be "polar opposites." This social life issue causes Wilson a great deal of frustration at times.
The Series
After finding the answer, he suffers a seizure and slips into a coma where he imagines an emotionally wrenching conversation with Amber, who died. He confesses he doesn't want to wake up because it doesn't hurt in this in-between world and he doesn't want to live in a world where Wilson hates him. What makes this admission so poignant is that it's one of the first times House really ever acknowledges how much Wilson means to him. Furthermore, House spends most of his life avoiding pain, but that's not an option here. Still crying over a fictional character's death from a movie you saw years ago? Having trouble letting go of that one episode of your favorite series?
Treatment Options
In the Season 6 episode, Open and Shut, this proves to be a challenge with his attempt to get back together with Sam. Wilson becomes annoyed when Sam puts the milk in the door shelf of the refrigerator, saying that it would be colder in the center, thus less likely to become spoiled. Wilson originally tries to ignore his annoyance with Sam not being as cautious as he is, and says nothing to her about it at first. However, House notices and uses it to try to test and sabotage the strength of Wilson's re-emerging relationship with Sam, by off-setting the dishes in the dishwasher so that there's a big bowl on the bottom shelf that blocks the water from getting to the top shelf. Thinking that Sam also did that, and not knowing it was actually House's "testing", Wilson finally asks Sam if she could be more cautious with germs, and also if she could use a coaster with her drinks on his furniture. Sam becomes surprised when he brings up and asks for all of that at once, though eventually becomes glad that, unlike before, Wilson is expressing his annoyances.
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House finally relents when he takes a lengthy period of time to solve a case. At the same time, House's leg pain starts to return and he asks Wilson for Vicodin. Wilson refuses, figuring that House is merely suffering aches and pains from overdoing his rehabilitation. However, House responds by stealing one of Wilson's prescription pads and forging his signature. Fearing that his wife is angry with him for his latest infidelity, he instead finds out that she has been cheating on him. Initially, House makes out like he wants Wilson to leave as soon as possible, but instead House erases messages from potential landlords, and then tries to make Wilson's life as difficult as possible by stealing his food and refusing to clean up.
Lovers
This trait makes Wilson the only person who is willing to be with House on such a close and personal level of friendship. Shortly after graduating from medical school, Wilson decided to take some time off to attend a medical convention in New Orleans, Louisiana before starting his own internship. While he was at the convention, his wife had him served with divorce papers (the first time he knew Sam was dissatisfied with their marriage). While mulling the matter over at a bar, he got upset with a doctor who kept playing Billy Joel's "Leave A Tender Moment Alone" on the jukebox. Wilson is by all standards one of the nicest people you could meet, as he has an unbelievable bedside manner and knows exactly how to talk to people. He also cares deeply about others, sometimes even more than he cares about himself.
Wilson and House's friendship is deep but not infrequently volatile; while it’s usually good-natured on the surface it can also be excessively competitive and harsh – especially from House’s end. For example, when arguing about how to treat a patient, House tells him, "I can handle it when things go wrong. You can't. And things could go very, very wrong." Though they often point out the flaws in each other, they’re very dependent on their relationship, even if they would never admit it. He is diagnosed with stage II thymoma in the Season 8 episode "Body and Soul" and given six months to live.
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Character biography
In the Season 6 episode, Wilson, he noticed that a Cancer patient, who was in remission, did not brag about his grand kids like usual. While a seemingly minute happening, especially for a Cancer patient, Wilson thought that the patient's subtle increase of depression could be the result of new Cancer. Having done some tests as a result, there indeed was a newly formed, small Cancerous mass in the patient's lung, which didn't end up doing much harm, due to the very early catch. Wilson was then congratulated for this finding, from his attention to detail, at a board meeting. His perceptiveness also helps him accurately interpret things that House is saying, including when House lies or denies his true motives, on many occasions. Wilson also occasionally gets petty, such as with germs and keeping food safe, and with keeping his furniture clean.
House plans on spending his remaining time with Wilson, but one of House's pranks goes horribly wrong which results in the revocation of House's parole and his imminent return to jail that will see Wilson die during House's time in prison. In the aforementioned coma dream, Laurie is heartbreakingly vulnerable and comes across as a great man finally stripped of all of his pretensions. As a desperate man refusing to accept the reality that the (current) love of his life is dying, Leonard delivers an equally devastating performance that remains incredibly grounded and never becomes maudlin.
The detective soon turns up the heat on Wilson by having his car towed and suspending Wilson's ability to prescribe narcotics to his patients. Wilson tries to get Allison Cameron to sign off on his prescriptions, but when House calls her away to work on his case, Wilson instead gives up his oncology practice. Wilson also finds out that House borrowed money from him to buy a motorcycle even though House had enough money already. House admits that he borrowed the money to see how much he could borrow before Wilson refused.
Wilson moves around a lot – a few failed marriages and relationships haven’t helped – even staying with his colleague and best friend, Dr. Gregory House, for a while. However, Wilson defends House when House's career is in jeopardy, after billionaire entrepreneur and then chairman of Princeton-Plainsboro's Board Edward Vogler (Chi McBride) proposes a motion for House's dismissal.[6] Wilson is the only one to vote against the motion. The term Hilson has been coined to describe those who support a romantic relationship between the two, and in the episodes Hunting, The Tyrant and The Down Low they have been mistaken for a gay couple.
However, Wilson refuses to cooperate, leaving House on his own but House soon agrees to treatment, remaining in Mayfield for seven weeks and is released into Wilson's care. Wilson encourages House to start a relationship with Cuddy, but their plans are thwarted when they discover she's dating Lucas Douglas. After House returns from his convalescence after being shot and having treatment that removes his leg pain albeit temporarily, he takes on the case of a former cancer patient who is confined to a wheelchair. After performing several dangerous procedures on the patient, House comes up with the seemingly crazy idea that the patient has Addison's disease and merely needs a shot of cortical. However, Cuddy refuses permission, only to give the patient the shot herself. As if by a miracle, the patient immediately improves, showing House was right but Wilson tells Cuddy she can't tell House as if she does, he'll never be controllable again.
This case isn't only personal because of Amber's connection to Wilson; House feels directly responsible for her death. James Evan Wilson was a major character on House from the first season until the end of the series. In an attempt to figure out what exactly is wrong with Amber, House undergoes deep brain stimulation to jog his memory of the night before.
This same misunderstanding has also been explored in modern interpretations of Sherlock Holmes, particularly the 2010 production "Sherlock" set in 21st century Great Britain where people often mistake Holmes and Watson for a gay couple. Although he plans to marry her, he finds out during a review of Sam's treatment records that she may have been overexposing terminal cancer patients to radiation in a last ditch effort to save them. Although he is supportive, Sam treats this as evidence that Wilson doesn't trust her and breaks up with him. When an old friend and patient of Wilson's needs a liver transplant, Wilson finally agrees and House shows up just before the operation for support even though he thinks it's a bad idea. House is there for the rehabilitation as well, and Wilson soon regrets his decision when the friend goes back to his new girlfriend instead of his ex-wife.
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